Effect of TSH Suppression Therapy on levels of TSH , T 4 and T 3 Swathi

Objectives – To find the effect Of TSH suppression therapy on levels of TSH, T4 and T3 in hypothyroidism. Methods The study comprised of 40 subjects, classified into 2 groups each, with 20 subjects. Group I – 20 (Healthy individuals) controls aged between 20 – 45 years with euthyroid status. Group II20 Hypothyroid subjects with suppressed levels of TSH aged between 20 to 45 years. The parameter like T3, T4, TSH measured. Results – The mean value of TSH were 2.42+1.08 in controls and 0.15+0.00 in hypothyroid treated, the mean value of T4 were 98.45+21.92 in controls and 139.65+37.90 in hypothyroid treated, the mean value of T3 were 1.25+0.33 in controls and 1.36+0.48 in hypothyroid treated. Conclusion The Mean value of TSH is much less in subjects and is statistically significant. Serum T4 and T3 levels are higher in subjects compared to controls and serum T3 changes are not significant. Serum T4 changes are significant. As a result of treatment with L-thyroxine there is an high levels of serum T4 and T3.